Did you know the DDC/CI (Display Data Channel / Command Interface) standard was introduced in August 1998? It allows you to modify some of your monitor’s settings just by being connected to your PC, instead of changing them via the annoying buttons on the monitor’s side.
You can check if your monitor supports DDC/CI from its settings, usually you have the option to enable/disable it. The monitor’s specifications or technical sheet may list this information.

Thankfully, you don’t have to open CMD or anything; there are smart people out there that have already created apps for your comfort. And some are open-source!

I’m using Monitorian (open-source & free) on Windows. It has a nice tray icon that you can click to reveal sliders for changing brightness and contrast. An odd thing about my monitor is that I cannot change the its saturation settings from the OSD1, so I don’t have a saturation slider; if your monitor lets you change its saturation, Monitorian will probably display a slider too.

On MacOS you can try Monitor Control (open-source & free) or Lunar (open-source maybe, I have no idea).

On Linux you can search for a repository yourself https://github.com/search?q=ddc%2Fci&type=repositories (open-source, ofc).

Notes

  1. On-Screen Display: that rectangle with settings that appears only when you manually touch the settings buttons.